Parkinson’s is a progressive condition affecting the brain, for which there is currently no cure.
Existing Parkinson’s treatments can help with some of the symptoms but can’t slow or reverse the loss of neurons that occurs with the disease.
Terazosin may help by activating an enzyme called PGK1 to prevent this brain cell death, the researchers, from the University of Iowa, in the US and the Beijing Institute for Brain Disorders, China, say.
When they tested the drug in rodents it appeared to slow or stop the loss of nerve cells.
To begin assessing if the drug might have the same effect in people, they searched the medical records of millions of US patients to identify men with BPH and Parkinson’s.
They studied 2,880 Parkinson’s patients taking terazosin or similar drugs that target PGK1 and a comparison group of 15,409 Parkinson’s patients taking a different treatment for BPH that had no action on PGK1.
Patients on the drugs targeting PGK1 appeared to fare better in terms of Parkinson’s disease symptoms and progression, which the researchers say warrants more study in clinical trials, which they plan to begin this year.
Lead researcher Dr Michael Welsh says while it is premature to talk about a cure, the findings have the potential to change the lives of people with Parkinson’s.
“Today, we have zero treatments that change the progressive course of this neurodegenerative disease,” she says.
“That’s a terrible state, because as our population ages Parkinson’s disease is going to become increasingly common.
“So, this is really an exciting area of research.”
Given that terazosin has a proven track record for treating BPH, he says, getting it approved and “repurposed” as a Parkinson’s drug should be achievable if the clinical trials go well.
The trials, which will take a few years, will compare the drug with a placebo to make sure it is safe and effective in Parkinson’s.
Co-researcher Dr Nandakumar Narayanan, who treats patients with Parkinson’s disease said: “We need these randomised controlled trials to prove that these drugs really are disease modifying.
“If they are, that would be a great thing.”
Prof David Dexter from Parkinson’s UK said: “These exciting results show that terazosin may have hidden potential for slowing the progression of Parkinson’s, something that is desperately needed to help people live well for longer.
“While it is early days, both animal models and studies looking at people who already take the drug show promising signs that need to be investigated further.”
Your pooch may be the apple of your eye, but did you know you can take her to pick apples with you, too? Many farms and orchards around the country welcome four-legged guests. Not only can you use apples to make delicious apple pies, apple cider and apple butter, but your pup can enjoy the fruit as well! According to the American Kennel Club, apples are safe for dogs to eat, in moderation of course. However, dogs should not consume the seeds because they contain a plant compound that converts into cyanide when chewed. The core should also be kept away from pups, as it could be a choking hazard.
Deardorff Orchards loves dogs, which is why they have two separate pet water stations on the premises as well as waste bags available for guests with pups. Dogs are welcome on their 125 acres of grounds if they’re leashed and friendly. You and your pup will be able to pick from their 10 varieties of apples, and their 3,000 trees ensure you can have your pick of the litter. Deardorff Orchards also has pumpkins, red wagons if you want to tow along your kids or your exceptionally lazy dog, and farm animals for Fido to meet. Guests are welcome to enjoy the barn, listen to live music, sample their wines, and take a tractor ride on the weekends. If your furry travel companion still isn’t ready to go home after a trip to the farm, visit dog-friendly Minneapolis, which is only about an hour away.
Pick-Your-Own apples is available at Deardorff Orchards Fridays to Sundays from September 5 through late October. Depending on the weather, apple picking is open from noon until 5 p.m. Customers must purchase at minimum a half-peck bag (roughly six pounds) before heading to the orchard. The cost varies depending on the apple variety and availability.
Just a short drive from Asheville (and about two hours from Charlotte), Grandad’s Apples has been family-owned and operated since 1994. Pups and people alike can enjoy the 100 acres of the farm. Leashed dogs can join you while picking apples from the orchard but are not allowed in the pumpkin and playground areas. Fido is welcome inside the Barn and Country Store (where you can shop for apple turnovers, hot cider donuts, caramel apples and other goodies), near the barnyard corral where he can hang out with the resident farmyard animals, and in their 5-acre corn maze. Weekends at Grandad’s are full of fun events like cow trains, jump pillows, and even an apple cannon!
Grandad’s Apples is open for apple picking from late July through the third week of October from 8 a.m. to 6 p.m. daily. Pick-Your-Own is $11 for a peck and $18 for a half bushel. The corn maze is $4 per person and free for dogs. They recommend calling ahead to learn what’s available for picking before visiting.
My fur coat really makes the apples pop.”
Photo by Facebook.com/WrightsFarm
Your pooch will love exploring Wrights Farm’s vast 453 acres. In addition to picking from the 100,000 bushels of apples they grow every year, you and Fido can hike, bike, picnic or tailgate here. They even welcome you to bring gas grills, kites and frisbees. The farm, which has been family-run for five generations, also offers Pick-Your-Own pumpkins and sells a variety of fruits, vegetables, baked goods, jams, jellies, pickles and apple sauces.
You can pick apples at Wrights Farm from September 8 to November 3, 2019. Pick-Your-Own hours are from 8 a.m. to 4:30 p.m every day. Admission is $12 and includes a one-peck bag. Children 5 to 9 years old pay $6 and receive a ½-peck bag. Children under 5 and dogs are free. Additional bags are available for purchase.
Dogs are part of the family, which is why leashed pups are invited to create fall memories along with everyone else at Kiyokawa Family Orchards. The family-owned and operated business has been growing produce (more than 120 varieties of apples and pears today!) since 1911. Dogs can lend a helping paw in the orchards. However, they may not enter the fruit stand. There is a water bowl for your pup to cool off and waste bags are available for easy cleanup. After you get your selection from the largest U-Pick orchard in the valley, don’t forget to snap some photos of Fido with the gorgeous backdrop of Mt. Hood.
Kiyokawa Family Orchards is open Saturdays and Sundays from July 13 to August 30 from 9 a.m. to 6 p.m. From August 30 to November 4, operating hours are Monday to Friday from 10 a.m. to 6 p.m. and weekends from 9 a.m. to 6 p.m. There is no admission fee and fruit prices vary.
Terison Apple Orchard gets it. One of their owners has her own pet-sitting service, so they understand how much people love their pooches. Leashed dogs can help you pick apples in their low-spray orchard. It’s the first Pick-Your-Own orchard in Maine, and you and your pup can bond together while savoring the sweet fruits of your labor.
While exact dates and hours vary due to the weather, Terison Apple Orchard is generally open from early September through October, from 9 a.m. to 5 p.m. daily. The orchard is self-service and uses the honor system. Bags cost $10 and $20, payable by cash only.
Apple picking with your pup can be a real balancing act.
Photo by Facebook.com/ciderhillfamilyorchardLeashed furry family members can help you pick from 18 different types of apples at Cider Hill Family Orchard’s 1,500 apple trees. Dogs are welcome on the 38 acres of farmland, but they may not enter buildings including the gift shop. Cider Hill also has a pumpkin patch, a fishing pond, a fire pit, hayrides and kid’s train rides. While you’re here, don’t forget to sample delicious treats made on site like cinnamon-cider doughnuts, apple crisp, kettle corn and apple butter.
Apple picking at Cider Hill begins in August. However, the end of the season varies due to the weather. In August, operating hours are 9 a.m. to 5 p.m. Tuesday through Saturday. In September and October, operating hours are 9 a.m. to 5 p.m Tuesday through Saturday and noon to 5 p.m. on Sunday. There is no admission fee. A peck of apples is $11, a half bushel is $21, and a bushel is $40. Aggressive dogs are not permitted.
Applecrest Farm is not only the oldest continuously operated apple orchard in America, and the oldest and largest in New Hampshire, it’s also dog friendly! Pups are welcome if they’re leashed, under control and picked up after. The farm boasts 220 acres and more than 40 types of apples. While dogs are not permitted in buildings or in the blueberry fields, you and Fido may enjoy the free tractor rides offered to and from the orchard on weekends in September and October. If your pup is itching for a road trip, the farm is conveniently located an hour from Boston and about 15 miles from historic Portsmouth and Newburyport.
Customers can pick apples from mid-August to late October from 8 a.m. to 5:30 p.m. daily. Admission is free. Pick-Your-Own apples are sold by the peck for $20 and by the half bushel for $30, payable by cash only.
“Now, how do I get out?”
Photo by @rogerdawgHilltop Orchards uses eco-farming methods to grow no-residue apples, which you and your leashed pup can pick together. The family-run property sits on 200 acres and grows 26 varieties of apples, most of which are available for Pick-Your-Own. On weekends during peak season, they offer free hayrides for two-legged and four-legged guests alike from 11 a.m. to 5 p.m. Hilltop Orchards also allows visitors with pets to use their land for hiking, skiing and snowshoeing. In addition, furry visitors can join you for wine and/or hard cider tastings at their on-site Furnace Brook Winery.
Apple season at Hilltop Orchards runs from Labor Day through Columbus Day, although they often have limited availability before and after these dates. The orchards are open daily from 9 a.m. to 5 p.m. A half peck costs $7, a peck costs $10, and a half bushel costs $20.
Minnetonka Orchards is very dog friendly. Dogs are welcome in all 12 acres of apple orchards and even on hayrides. They only ask that dogs are leashed and picked up after. The orchards, which have been around since 1976, feature 12 types of apples. The grounds also include Cinderella pumpkin patches and fields of gourds and squash. Other activities include a petting zoo, a tree deck, a corn maze, nature trails and several kids’ play areas. Tasty snacks like apple donuts and brats are also available for purchase. Their sister company, Painter Creek Winery & Cidery, allows dogs as well.
Minnetonka Orchards is open daily from late August through October. Hours of operation are from 10 a.m. to 7 p.m. The admission fee varies based on the crop but includes access to all the attractions on the premises.
Alldredge Orchards welcomes dogs to pick apples with their owners as long as they’re leashed and cleaned up after (and you let them pet your pooch!). They grow several varieties which vary year to year depending on the weather. The property also has a pumpkin patch, barn store, cafe, playground and farm animals, so there’s plenty of fun for the whole family.
Alldredge Orchards is open from Labor Day Weekend through October. Guests can pick apples during the weekends from 10 a.m. to 5 p.m. Admission is $3 for ages 2 and up. Prices for apples are based on the crop and availability, and they recommend calling ahead before visiting.
Doe Orchards has offered Pick-Your-Own apples since the 1960s and has no plans of stopping now. Leashed four-legged guests are allowed during the fall as long as their two-legged companions clean up after them. Doe Orchards also has pumpkins, gourds, honey and cider. There are plenty of areas for picnicking after a long day of fruit-filled fun.
Apple picking usually begins Labor Day weekend (but may be a little later this season due to weather) and ends in mid-October. Hours of operation are 10 a.m. to 5 p.m. daily. Prices in 2018 were $17 for a peck and $30 for a half bushel.
West Valley U-Pick offers a great pesticide-free option for you and your pup, not to mention it was named one of Washington’s top 10 apple picking spots. Leashed dogs are welcome anywhere on the property to help you sniff out your perfect pick of apples or other seasonal fruits and veggies. If your pooch really wants to feel accomplished, you can even use one of the orchard’s old-fashioned hand-cranked cider presses to make your own cider.
Fido can pick apples Monday through Saturday 8 a.m. to 7 p.m. and Sunday 8 a.m. to 5 p.m. from late August until the end of September. There is no admission fee for two- or four-legged pickers. Apples are $0.85 per pound and cider presses may be used for free with the purchase of U-Pick apples–simply bring your own container or purchase one of theirs.
Dogs are welcome to join you at DeMeritt Hill Farm as long as they are leashed at all times. Don’t worry if you forget one! Leashes are available for rent or purchase at their store. There are trash bins throughout the property for easy cleanup after your pup. Dogs are allowed on the orchard grounds (with 25 apple varieties) and trails, just not in the buildings or on the hayrides.
The farm gives back to animals as well. Every October, it hosts Haunted Overload, a Halloween attraction that benefits the Pope Memorial Humane Society. Dogs are allowed during day haunts but are not permitted at night. The annual “spooktacle” has been voted one of the top haunted attractions in the country multiple times, and even won “The Great Halloween Fright Fight’” on ABC. The $50,000 grand prize from the show was donated to the Humane Society.
DeMeritt Farms is open for apple picking from late August through October. Pick-Your-Own is available Wednesday through Sunday from 10 a.m. to 5 p.m. There is no admission fee, but customers must purchase a one-peck bag before entering the orchard. The price depends on the type of apple but is typically around $16 per peck.
Yes, I know they are selling apples but nonetheless the photographs are so good that as far as I am concerned the post is a big plus!
When Toni Morrison died on Aug. 5, the world lost one of its most influential literary voices.
But Morrison wasn’t a literary wunderkind. “The Bluest Eye,” Morrison’s first novel, wasn’t published until she was 39. And her last, “God Help the Child,” appeared when she was 84. Morrison published four novels, four children’s books, many essays and other works of nonfiction after the age of 70.
Morrison isn’t unique in this regard. Numerous writers produce significant work well into their 70s, 80s and even their 90s. Herman Wouk, for example, was 97 when he published his final novel, “The Lawgiver.”
Such literary feats underscore an important point: Age doesn’t seem to diminish our capacity to speak, write and learn new vocabulary. Our eyesight may dim and our recall may falter, but, by comparison, our ability to produce and to comprehend language is well preserved into older adulthood.
Some aspects of our language abilities, such as our knowledge of word meanings, actually improve during middle and late adulthood.
One study, for example, found that older adults living in a retirement community near Chicago had an average vocabulary size of over 21,000 words. The researchers also studied a sample of college students and found that their average vocabularies included only about 16,000 words.
In another study, older adult speakers of Hebrew – with an average age of 75 – performed better than younger and middle-aged participants on discerning the meaning of words.
On the other hand, our language abilities sometimes function as a canary in the cognitive coal mine: They can be a sign of future mental impairment decades before such issues manifest themselves.
In 1996, epidemiologist David Snowdon and a team of researchers studied the writing samples of women who had become nuns. They found that the grammatical complexity of essays written by the nuns when they joined their religious order could predict which sisters would develop dementia several decades later. (Hundreds of nuns have donated their brains to science, and this allows for a conclusive diagnosis of dementia.)
While Toni Morrison’s writing remained searingly clear and focused as she aged, other authors have not been as fortunate. The prose in Iris Murdoch’s final novel, “Jackson’s Dilemma,” suggests some degree of cognitive impairment. Indeed, she died from dementia-related causes four years after its publication.
Don’t put down that book
Our ability to read and write can be preserved well into older adulthood. Making use of these abilities is important, because reading and writing seem to prevent cognitive decline.
Keeping a journal, for example, has been shown to substantially reduce the risk of developing various forms of dementia, including Alzheimer’s disease.
Reading fiction, meanwhile, has been associated with a longer lifespan. A large-scale study conducted by the Yale University School of Public Health found that people who read books for at least 30 minutes a day lived, on average, nearly two years longer than nonreaders. This effect persisted even after controlling for factors like gender, education and health. The researchers suggest that the imaginative work of constructing a fictional universe in our heads helps grease our cognitive wheels.
Language is a constant companion during our life journey, so perhaps it’s no surprise that it’s interwoven into our health and our longevity. And researchers continue to make discoveries about the connections between language and aging. For example, a study published in July 2019 found that studying a foreign language in older adulthood improves overall cognitive functioning.
A thread seems to run through most of the findings: In order to age well, it helps to keep writing, reading and talking.
While few of us possess the gifts of a Toni Morrison, all of us stand to gain by continuing to flex our literary muscles.
Richard M. Roberts, a U.S. diplomat currently serving as the Public Affairs Officer at the U.S. Consulate General in Okinawa, Japan, is a contributing author of this article.
Roger J. Kreuz and Richard M. Roberts are the authors of:
Berkley Jensen Pig Ear Dog Chews Sold at BJ’s Wholesale Club Recalled
September 3, 2019 — Dog Goods USA is expanding its recent recall to include all 30-packs of Berkley Jensen brand pig ear dog chews sold at BJ’s Wholesale Club stores due to possible contamination with Salmonella.
The previous recall is being expanded after testing by Rhode Island Department of Health found Salmonella bacteria in Berkley Jensen brand pig ear pet chews.
What’s Being Recalled?
Dog Goods USA LLC of Tobyhanna, PA, has been contacted by the FDA and is conducting a voluntary recall of the following products: non-irradiated bulk and packaged pig ears branded Chef Toby Pig Ears with the lot codes indicated below.
The affected products were distributed nationwide in retail stores.
What Caused the Recall?
According to the company, Dog Goods USA purchased the affected treats from a single supplier in Brazil from September 2018 through August 2019.
The U.S. Food and Drug Administration, together with the Centers for Disease Control and Prevention and State partners, is investigating a link between pig ear pet treats and human cases of salmonellosis.
Healthy people infected with Salmonella should monitor themselves for some or all of the following symptoms: nausea, vomiting, diarrhea or bloody diarrhea, abdominal cramping and fever.
Rarely, Salmonella can result in more serious ailments, including arterial infections, endocarditis, arthritis, muscle pain, eye irritation, and urinary tract symptoms.
Consumers exhibiting these signs after having contact with this product should contact their healthcare providers.
Pets with Salmonella infections may be lethargic and have diarrhea or bloody diarrhea, fever and vomiting.
Some pets will have only decreased appetite, fever and abdominal pain.
Infected but otherwise healthy pets can be carriers and infect other animals and humans.
If your pet has consumed the recalled product and has these symptoms, please contact your veterinarian.
Dog Survives 31 Days In Woods After Being Hit By Car
By LINDSAY NADRICH, KGW-TV
VANCOUVER, Wash. (AP) — Niko, a Vancouver family’s dog, survived 31 days in the wilderness after getting hit by a car.
Niko is 16-year-old Caden Alt’s adventure partner.
“He’s always fun to have around,” Caden told KGW-TV. “He’s right there at your side walking around and yeah, he’s just awesome.”
On July 26, Niko went camping with Caden’s father, David Alt, in the Gifford Pinchot National Forest. Later that night, Niko wandered over to the road and got hit by a car. David ran from the campsite just in time to see Niko sprint off into the woods.
“A lady jumped out of the car immediately and said, ‘I don’t know how he could’ve survived that,'” he said.
He searched all night, but could not find Niko. He said it was devastating.
For the next 31 days, he and Caden spent as much time as they could going back to look.
“Every weekend we went up there, we searched, that was pretty hard, coming back every day not finding anything,” Caden recalled.
Then last weekend, they got a call from two men who had seen a post about Niko on Facebook and spotted him about 100 yards from where he disappeared.
“That was, just like, my heart dropped for a second, like, is this happening?” Caden asked.
The Good Samaritans canceled their own trip and drove Niko straight to Vancouver.
“So, yeah, my son and I were just crying, it was, it was unbelievable, yeah, and then of course when we’re in the driveway and they bring him up, Caden and I are crying, those two grown men are crying, four guys crying, it was great,” David said.
Niko lost about 15 pounds but is otherwise doing well.
“Skin and bones and one eye shut, he had lost 30% of his body weight, but he immediately was eating and drinking,” David said.
Niko seemed pretty happy to be back by Caden’s side.
“It’s been amazing,” Caden said. “I’m so glad to have him back. He’s not like perfect, energetic back up to himself, but he’s getting there, better every day. He’s just as cute as ever, the house is filled again.”
So what did Niko do for 31 days alone in the woods?
“As far as trying to recap, only Niko knows the story right, too bad he couldn’t tell it,” David said.
During the month Niko was missing, David and Caden said they got a lot of support from people on social media, as well as a lot of tips that helped with the search. They said they are so thankful for everyone who kept them going.
Specifically Aunt Jeni’s Home Made frozen raw pet food.
Here are the details.
FDA Warning: Do Not Feed Certain Lots of Aunt Jeni’s Dog Food
August 30, 2019 — The U.S. Food and Drug Administration is warning pet ownersnot to feed their pets certain lots of Aunt Jeni’s Home Made frozen raw pet food.
That’s because 2 samples collected during an inspection of the company’s product tested positive for Salmonella and/or Listeria monocytogenes.
FDA is issuing this warning since these lots of Aunt Jeni’s Home Made frozen raw pet food represent a serious threat to both human and animal health.
Because the products are sold and stored frozen, FDA is concerned that people may still have them in their possession.
No product images have been provided by the FDA or the company.
Which Products Are Affected?
The affected products include:
Aunt Jeni’s Home Made Turkey Dinner Dog Food
Package size: 5 pounds (2.3kg)
Lot number: 175199 JUL2020
Aunt Jeni’s Home Made Chicken Dinner Dog Food
Package size: 5 pounds (2.3kg)
Lot number: 1152013 JUL2020
Aunt Jeni’s Home Made pet foods are sold frozen both online and through various retail locations. Lot codes are printed on the lower right corner of the front of each bag.
Salmonella is a bacterium that can cause illness and death in humans and animals, especially those who are very young, very old, or have weak immune systems.
According to CDC, people infected with Salmonella can develop diarrhea, fever and abdominal cramps.
Most people recover without treatment. However, in some people, the diarrhea may be so severe that they need to be hospitalized.
In some patients, the Salmonella infection may spread from the intestines to the blood stream and then to other body sites unless the person is treated promptly with antibiotics.
Consult your health care provider if you have symptoms of Salmonella infection.
Pets do not always display symptoms when infected with Salmonella.
However, signs can include vomiting, diarrhea (which may be bloody), fever, loss of appetite and/or decreased activity level.
If your pet has these symptoms, consult a veterinarian promptly.
You should also be aware that infected pets can shed the bacteria in their feces and saliva without showing signs of being sick, further contaminating the household environment.
Like Salmonella, Listeria monocytogenes is another bacterium that can cause illness and death in humans and animals, especially those who are pregnant, very young, very old, or have weak immune systems.
According to CDC, listeriosis in humans can cause a variety of symptoms, depending on the person and the part of the body affected.
Symptoms can include headache, stiff neck, confusion, loss of balance, and convulsions in addition to fever and muscle aches.
Pregnant women typically experience only fever and other flu-like symptoms, such as fatigue and muscle aches.
However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn.
Pregnant women and their newborns, adults age 65 and older, and people with weakened immune systems are more likely to get sick with listeriosis.
Anyone with symptoms of listeriosis should contact a health care provider.
Listeria infections are uncommon in pets. However, they are still possible.
Symptoms may include mild to severe diarrhea, anorexia, fever, nervous, muscular and respiratory signs, abortion, depression, shock and death.
Pets do not need to display symptoms to be able to pass Listeria on to their human companions.
As with Salmonella, infected pets can shed Listeria in their feces and saliva without showing signs of being sick, further contaminating the household environment.
What to Do?
If you have any of the affected product, stop feeding it to your pets and throw it away in a secure container where other animals, including wildlife, cannot access it.
Consumers who have had this product in their homes should clean refrigerators and freezers where the product was stored.
Clean and disinfect all bowls, utensils, food prep surfaces, pet bedding, toys, floors, and any other surfaces that the food or pet may have had contact with.
Because animals can shed the bacteria in the feces when they have bowel movements, it’s important to clean up the animal’s feces in yards or parks where people or other animals may become exposed.
Consumers should thoroughly wash their hands after handling the affected product or cleaning up potentially contaminated items and surfaces.