Category: Innovation

Dogs are saving our lives!

Literally, not just emotionally!

Over on my website, under My Writings, I mention my recently published booklet, The Amazing World of Dogs.

Here’s an extract from pages 17-18 of that booklet.

Finally, Dr. Morten Kringelbach of the Department of Psychiatry at Oxford University1 explains that the need to nurture is very deep in us humans and that dogs produce an instinctive parental response in us that is very similar to our nurturing instinct for our children.

If the magic of having dogs in our lives for such a long time ended there it would still be breathtakingly wonderful. But dogs could now be offering us humans the capacity to understand many human diseases. Literally, our dogs could be saving our lives!

The challenge in understanding human diseases is that within our ‘breed’ there is a great variability of genes. Not surprising when one considers the incredible diversity and variation within us humans.

But when we turn to dogs then we have a bonus. For despite there being, as mentioned earlier, 400 or more different breeds of dog, within each breed dogs are very similar to each other. In other words, that narrow gene pool within a specific dog breed makes if far easier to pinpoint genetic mutations than it is in humans.

Elinor Karlsson is the director of the Vertebrate Genomics Group at the Broad Institute of MIT and Harvard.2 As a geneticist, Dr. Karlsson has identified, “hundreds of diseases common to dogs and humans”. In 2005, the dog’s genome was fully mapped; all 2.4 billion letters of the dog’s genome

Among those common diseases between us humans and our wonderful dogs are diabetes, cardiac diseases, epilepsy, many cancers especially bone cancers, and breast cancer and even brain tumours.

So it was an obvious thing to do to republish the following article that appeared on the Care2 site a few days ago.

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 Could a Dog Vaccine Help Save Kids With Brain Cancer?

By: Laura Goldman April 17, 2017

About Laura Follow Laura at @lauragoldman

The statistics are grim: About 60 to 70 percent of children who have glioblastoma, a form of brain cancer, do not survive more than two years. This fast-growing cancer is resistant to traditional treatments like radiation and chemotherapy.

For dogs, cancer statistics are also grim. More than 6 million dogs are diagnosed with cancer every year, and one out of four dogs will get cancer during their lifetime. It’s the leading cause of death for dogs after the age of two.

But there could be hope for both dogs and kids. A vaccine being developed that destroys cancer cells in dogs could also be successful in fighting glioblastoma in children.

Researchers at Children’s Mercy Hospital in Kansas City, Mo., have started a partnership with ELIAS Animal Health, a company that’s testing treatments for osteosarcoma (bone cancer) and B cell lymphoma in dogs.

“If we take advantage of the resources we have in this region and get behind those collaborations, this could be a mecca for advanced, exciting, innovative therapies for cancer and lots of other diseases,” Dr. Doug Myers, an oncologist at Children’s Mercy, told the Kansas City Star.

ELIAS Cancer Immunotherapy (ECI) uses the dog’s own immune system to destroy the cancer. “Research has shown that ex vivo activated T cells have the machinery to effectively kill cancer cells, including cancer stem cells,” according to the company’s website. “ELIAS Cancer Immunotherapy utilizes adoptive cell therapy to deliver an army of activated T cells.”

The dog is vaccinated with his own cancer cells to produce an immune response, then the generated white blood cells destroy the cancer cells.

“Personalized T cells are then safely obtained from the patient through apheresis [the removal of blood] and then ‘super charged’ to produce a large population of killer T cells that are reinfused into the patient to kill the cancer,” the company explains.

ELIAS Animal Health is currently conducting clinical trials of ECI at Kansas State University, the University of Missouri-Columbia and a few animal hospitals across the country. The success rates of using ECI along with surgery on dogs with cancer are being compared with those of patients that are treated with surgery alone.

“Early clinical study results already show positive outcomes,” Tammie Wahaus, CEO of ELIAS Animal Health, said in November 2016.

Among the ECI success stories is that of Dakota, a German shorthaired pointer who continues to survive a year after she was diagnosed with osteosarcoma. This is twice as long as her original prognosis. X-rays taken during a follow-up examination showed no signs of the cancer spreading.

Could ECI also successfully treat children with glioblastoma? Dr. Kevin Ginn, a pediatric oncologist at Children’s Mercy, and other researchers are currently developing protocols for trials. They’re planning to apply for a Phase II clinical trial with the U.S. Food and Drug Administration, using the results of ECI’s studies on safety and effectiveness as far as dogs are concerned. The Phase II trial would give ECI to a large group of children to see if it’s effective and further evaluate its safety.

Animal health trials are regulated by the U.S. Department of Agriculture. They are less expensive and proceed faster than FDA-regulated human trials, the Kansas City Star reports, “but successful human health treatments often bring a larger return on investment.”

In this case, a larger return on investment could be a win-win for children as well as dogs with cancer.

Photo credit: cgordon8527

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My booklet closes thus:

Many would extend that proficiency of dogs to include their sense of loyalty and forgiveness, to and of us humans, but that all pales into insignificance when compared to what our understanding of dogs is giving us.

No less than the capacity to help cure many of our diseases, to deeply understand the workings of the human mind, and above all else, to offer insight into our very existence.

That’s quite a relationship!

Quite a relationship indeed!

No place for amateurs!

Offering up a tribute to the work of a professional.

Many, many years ago when I was in business on my own account (1978-1986) I had the pleasure of getting to know Frank Tijou. He was running his own very successful business. But more important than that, Frank had this wonderful ability to explain what he had learned over his years of being an entrepreneur. One such learning was stick to what you really know and don’t try and do things that are best left to other professionals. In other words, don’t be an amateur when it comes to important matters.

Thus when some weeks ago I was strongly recommended by some local authors to have an author website, I looked around for a professional. I quickly came to find Christy Kiltz of Design! by Kiltz Internet Solutions.

Talk about finding a true professional.

Forgive me, I’m not coming at this in terms of an ego trip. I just want to promote what a wonderful job Christy did. (And not forgetting Emily’s grand design work.) (And most certainly not forgetting my darling Jeannie who did the image of the man in a flat cap with the dogs!)

Please go across to my new website: Paul Handover – Life Traveller.

The home page banner image from my website.

So in the words of American playwright Garson Kanin:

“Amateurs hope, professionals work.”

Thank you, Christy!

Thinking anew.

Humanity’s safe and viable future depends on seeing things very differently.

Next Tuesday is the 62nd anniversary of the death of Albert Einstein, the famous German theoretical physicist who died on the 18th April, 1955. He delivered many innovative ways of seeing our world way beyond his theory of relativity, one of the two pillars of modern physics (alongside quantum mechanics) (Ref: Wikipedia)

Why do I introduce today’s post with that reference to Mr. Einstein?

Because I wanted to share with you a recent essay from George Monbiot and an Einstein quotation seemed so apt an introduction.

We shall require a substantially new manner of thinking if mankind is to survive.

That essay from George Monbiot was published yesterday and is shared with you all with Mr. Monbiot’s full permission.

It is an essay that deserves being read slowly and carefully. Please take time aside to so do because it really does offer a new manner of thinking.

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Circle of Life

13th April 2017

By reframing the economy, Kate Raworth’s Doughnut Economics changes our view of who we are and where we stand.

By George Monbiot, published in the Guardian 12th April 2017

So what are we going to do about it? This is the only question worth asking. But the answers appear elusive. Faced with a multifaceted crisis  – the capture of governments by billionaires and their lobbyists, extreme inequality, the rise of demagogues, above all the collapse of the living world – those to whom we look for leadership appear stunned, voiceless, clueless. Even if they had the courage to act, they have no idea what to do.

The most they tend to offer is more economic growth: the fairy dust supposed to make all the bad stuff disappear. Never mind that it drives ecological destruction, that it has failed to relieve structural unemployment or soaring inequality, that, in some recent years, almost all the increment in incomes has been harvested by the top 1%. As values, principles and moral purpose are lost, the promise of growth is all that’s left.

You can see the effects in a leaked memo from the UK’s foreign office: “Trade and growth are now priorities for all posts … work like climate change and illegal wildlife trade will be scaled down.” All that counts is the rate at which we turn natural wealth into cash. If this destroys our prosperity and the wonders that surround us, who cares?

We cannot hope to address our predicament without a new worldview. We cannot use the models that caused our crises to solve them. We need to reframe the problem. This is what the most inspiring book published so far this year has done.

In Doughnut Economics: seven ways to think like a 21st-century economist, Kate Raworth reminds us that economic growth was not, at first, intended as a measurement of well-being. Simon Kuznets, who standardised the measurement of growth, warned: “the welfare of a nation can scarcely be inferred from a measure of national income.” Economic growth, he pointed out, measures only annual flow, rather than stocks of wealth and their distribution.

Raworth points out that economics in the 20th Century “lost the desire to articulate its goals.” It aspired to be a science of human behaviour: a science based on a deeply flawed portrait of humanity. The dominant model – “rational economic man”, self-interested, isolated, calculating – says more about the nature of economists than it does about other humans. The loss of an explicit objective allowed the discipline to be captured by a proxy goal: endless growth.

The aim of economic activity, she argues, should be “meeting the needs of all within the means of the planet.” Instead of economies that need to grow, whether or not they make us thrive, we need economies that “make us thrive, whether or not they grow.” This means changing our picture of what the economy is and how it works.

The central image in mainstream economics is the circular flow diagram. It depicts a closed flow of income cycling between households, businesses, banks, government and trade, operating in a social and ecological vacuum. Energy, materials, the natural world, human society, power, the wealth we hold in common: all are missing from the model. The unpaid work of carers – principally women – is ignored, though no economy could function without them. Like rational economic man, this representation of economic activity bears little relationship to reality.

So Raworth begins by redrawing the economy. She embeds it in the Earth’s systems and in society, showing how it depends on the flow of materials and energy, and reminding us that we are more than just workers, consumers and owners of capital.

The Embedded Economy. Graphic by Kate Raworth and Marcia Mihotich

This recognition of inconvenient realities then leads to her breakthrough: a graphic representation of the world we want to create. Like all the best ideas, her Doughnut model seems so simple and obvious that you wonder why you didn’t think of it yourself. But achieving this clarity and concision requires years of thought: a great decluttering of the myths and misrepresentations in which we have been schooled.

The diagram consists of two rings. The inner ring of the doughnut represents a sufficiency of the resources we need to lead a good life: food, clean water, housing, sanitation, energy, education, healthcare, democracy … . Anyone living below that line, in the hole in the middle of the doughnut, is in a state of deprivation.

The Doughnut. Graphic by Kate Raworth and Christian Guthier/The Lancet Planetary Health

The outer ring of the doughnut consists of the Earth’s environmental limits, beyond which we inflict dangerous levels of climate change, ozone depletion, water pollution, loss of species and other assaults on the living world. The area between the two rings – the doughnut – is the “ecologically safe and socially just space” in which humanity should strive to live. The purpose of economics should be to help us enter that space and stay there.

As well as describing a better world, the doughnut model allows us to see, in immediate and comprehensible terms, the state in which we now find ourselves. At the moment we transgress both lines. Billions of people still live in the hole in the middle. We have breached the outer boundary in several places.

Where we are now. Graphic by Kate Raworth and Christian Guthier/The Lancet Planetary Health

An economics that helps us to live within the doughnut would seek to reduce inequalities in wealth and income. Wealth arising from the gifts of nature would be widely shared. Money, markets, taxation and public investment would be designed to conserve and regenerate resources rather than squander them. State-owned banks would invest in projects that transform our relationship with the living world, such as zero-carbon public transport and community energy schemes. New metrics would measure genuine prosperity, rather than the speed with which we degrade our long-term prospects.

Such proposals are familiar, but without a new framework of thought, piecemeal solutions are unlikely to succeed. By rethinking economics from first principles, Raworth allows us to integrate our specific propositions into a coherent programme, and then to measure the extent to which it is realised. I see her as the John Maynard Keynes of the 21st-Century: by reframing the economy, she allows us to change our view of who we are, where we stand, and what we want to be.

Now we need to turn her ideas into policy. Read her book, then demand that those who wield power start working towards its objectives: human prosperity within a thriving living world.

www.monbiot.com

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 Please, wherever you are and whatever your plans are for this long weekend, do take great care of yourself and all your loved ones!

Out of this world!

Forgive my indulgence!

I wish I understood where my fascination with the night sky came from. Not that I am anything other than an amateur gazer (of the night sky, I should hasten to add!). I have never taken the trouble to gain any real knowledge.

Yet, some of the most serene moments of my life have been when I have been alone at sea under a night sky.

OK, that’s enough wallowing for anyone!

The last week has been an important one for those that take an interest in the planets in our solar system, or to be specific, take an interest in Jupiter.

For as EarthSky reported on the 8th April:

Today – April 8, 2017 – the planet Jupiter is closest to Earth for this year.

Yet yesterday was Jupiter’s opposition, when Earth flew between Jupiter and the sun, placing Jupiter opposite the sun in our sky. You’d think Jupiter was closest to Earth for 2017 yesterday as well … and yet it wasn’t. It’s closest to Earth for 2017 today, April 8, coming to within 414 million miles (666 million km).

EarthSky also included this image:

Jupiter at its April 7, 2017 opposition with the Great Red Spot and moons Io, Europa, and Ganymede (L to R). Photo by Rob Pettengill in Austin, Texas.

Then, Mother Nature Network yesterday presented more information:

Jupiter strikes a pose for Hubble portrait

April 12, 2017
Jaymi Heimbuch

During the month of April, Jupiter will be in opposition, meaning the planet is at its closest point to Earth. Thanks to the sun, it’s during this window that astronomers can enjoy a particularly close-up photo session that can help reveal how the planet’s atmosphere has changed over time by comparing it with previous such photos of the gas giant.

This photo of Jupiter was taken on April 3 by the Hubble Space Telescope when the enormous planet was 670 million kilometers (or about 416 million miles) from Earth. The photo shows the Great Red Spot, but it also shows something new: a weather feature called the Great Cold Spot, which is almost as large as its more well-known cousin.

“The Great Cold Spot is much more volatile than the slowly changing Great Red Spot, changing dramatically in shape and size over only a few days and weeks, but it has reappeared for as long as we have data to search for it, for over 15 years,” Tom Stallard, a planetary astronomer at the University of Leicester in the U.K. and lead author of the study, said in a statement.

The cold spot is nearly 15,000 miles by about 7,500 miles in size, and it’s dubbed the “cold” spot because it’s 200 degrees Kelvin (about 400 degrees Fahrenheit) cooler than the surrounding atmosphere.

The article included this stunning image of Jupiter.

Photo: A. Simon (GSFC)/NASA, ESA

Jaymi went on to write:

Here’s what some of the other details in the image mean:
The NASA/ESA Hubble Space Telescope reveals the intricate, detailed beauty of Jupiter’s clouds as arranged into bands of different latitudes. These bands are produced by air flowing in different directions at various latitudes. Lighter coloured areas, called zones, are high-pressure where the atmosphere rises. Darker low-pressure regions where air falls are called belts. Constantly stormy weather occurs where these opposing east-to-west and west-to-east flows interact. The planet’s trademark, the Great Red Spot, is a long-lived storm roughly the diameter of Earth. Much smaller storms appear as white or brown-coloured ovals. Such storms can last as little as a few hours or stretch on for centuries.

The Great Red Spot is an anticyclonic storm that is so large that Earth would fit inside it. That stormy spot — which is actually shrinking, though astronomers don’t know why — gives us a great perspective for understanding just how huge Jupiter is compared to our own blue dot in the solar system.

Finally, I’m taking the liberty of republishing in full an item that appeared on The Smithsonian site on April 7th.

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Hubble Snags Splendid Snapshot of Jupiter

The perfect photographic conditions make for a grand view of the gas giant

This snapshot shows Jupiter’s swirling, banded atmosphere and signature vortices. (NASA, ESA, and A. Simon (GSFC))
By Erin Blakemore
smithsonian.com
 April 7, 2017

It’s been 27 years since the Hubble Space Telescope went into orbit, and the geriatric observatory is still going strong. When the telescope recently trained its sights on the solar system’s largest planet, the results were spectacular—proof that for the stellar spectator, age is but a number.

The image above is the latest picture of Jupiter. The snapshot was taken by Hubble on April 3 with the help of the telescope’s Wide Field Camera 3, a high-res instrument that lets the telescope observe using different wavelengths. It combines light on the visible, ultraviolet, and infrared spectrum to create an image of a massive planet in constant atmospheric flux.

In a press release, the European Space Agency, which co-runs Hubble with NASA, said that Hubble was able to take advantage of the planet’s current opposition with Earth to take the close-up. At the moment, Jupiter is lined up perfectly with the sun, and Earth is lined up with both the sun and Jupiter. Think of it as a truly heavenly photographic opportunity—a chance to look at the planet head-on. Better yet, Jupiter’s position relative to the sun means that it’s brighter than at any other time of year, which lets telescopes trained on the gigantic planet see even more detail than usual.

As The Washington Post’s Amy B. Wang notes, there were no new discoveries in the picture per se, but that doesn’t mean there’s nothing to look at. As ESA explains, scientists will compare the photo to previous views of the planet to hopefully learn more about the atmosphere. And for the rest of us, there’s a strangely soothing view of Jupiter’s layered cloud bands and impressive vortices.

The gas giant is thought to have sucked up most of the space debris left over after the sun formed, grabbing dust and gas with gravity. Scientists think it has two times as much debris as all of the other bodies in the solar system combined—and all of that material swirls through cloud layers in its quickly-rotating atmosphere.

Since Jupiter doesn’t exactly have a surface, it has nothing to slow the spots and vortices that appear in its atmosphere. The most famous, the Great Red Spot, is thought to have been swirling around for more than 150 years, and even though it’s unclear which gases give it that red hue, it’s the planet’s most recognizable feature. As NASA writes, the cloudiness of Jupiter’s atmosphere makes it hard to understand what might be contributing to it. But that doesn’t decrease its allure.

Want to delve even further into the mesmerizing bands of a huge planet’s atmosphere? A high-res version of the snapshot is available online. And if you prefer seeing things live, it’s a great time to check out Jupiter through in the night sky. You can find Jupiter in the east right after the sun goes down—a massive mystery that’s brighter than any star.

Read more: http://www.smithsonianmag.com/smart-news/hubble-snags-splendid-snapshot-jupiter-180962832/#2QLP7buDDb5PJaGK.99
Give the gift of Smithsonian magazine for only $12! http://bit.ly/1cGUiGv
Follow us: @SmithsonianMag on Twitter

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Let me finish up with another incredible fact.

Namely, that the universe came into existence some 13.82 billion years ago. The power of natural evolution that came with that event eventually brought along homo sapiens some 200,000 years ago. 200,000 is 0.0000145 of 13.82 billion.

Or to put it another way, we humans have only been a part of this universe for 1/10th of 1% of the life of said universe! (Oh, and dogs came along 100,000 years ago!)

A Hop, Skip and a Jump!

Actually it’s just about skipping! A dog skipping!!

This was seen on the BBC News website yesterday and I am delighted that the video clip is on YouTube.

Here’s how the story was reported by the BBC.

Devon dog sets skipping world record

3 April 2017 Last updated at 12:17 BST

A skipping Jack Russell and her owner have set a new world record.

Eight-year-old Jessica and her owner Rachael Grylls, from Lewdown in Devon, clocked up 59 skips in one minute.

The owner of a skipping Jack Russell dog says she is “really, really, really pleased” she and her pet have set a new world record.

Rachael said: “It’s quite hard to keep jumping, talking and rewarding her at the same time. I think I’m more unfit than Jessica!”

Lovely to see this news item from my old County of Devon.

You see, I used to live just a few miles out of Totnes in Devon; in the village of Harberton. Lewdown is also in Devon, as the news item reported, but it is the other side of Dartmoor. In other words, North-West of Dartmoor as opposed to Totnes being to the South-East of Dartmoor.

But if any of you dear readers fancy a vacation in the UK you should make a point of going to see Dartmoor. It’s a very beautiful place. (Sue, you have probably been to Dartmoor? Yes?)

Classic Dartmoor view

 

The Scent Angels

The endless miracles of having dogs in our lives.

I have two sisters: Elizabeth and Eleanor. Elizabeth lives in Tokyo, Japan and Eleanor lives in Johannesburg, South Africa. They are both dear sisters and we all love each other as brothers and sisters should!

Anyway, Eleanor’s husband, Warwick, has a brother and this story is about Warwick’s brother’s step-daughter, Stacey Maguire.

It was Eleanor who sent this story to me to be published in this place.

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My dog saves my life every day

Stacey Maguire’s life is always in danger.

A severe Type 1 Diabetic, her body doesn’t produce the insulin it needs to control her blood sugar, leaving her vulnerable to catastrophic changes in sugar levels. But as long as her dog, Gretchen, is around she has nothing to fear. For Gretchen is a trained Diabetic Assist Dog (DAD).

Gretchen is a Swiss Shepherd who saves her owner’s life on a daily basis by warning her whenever her blood sugar is at a dangerous level. Incredibly, Gretchen does this by smell.

Stacey’s chronic condition is so severe that she’s on the best monitoring technology in South Africa. But before Gretchen came into her life, and even with that monitoring technology, Stacey still experienced hypoglycemic episodes and seizures at least once a week when changes in her blood sugar levels weren’t detected in time.

Thus when Gretchen arrived from America her sole objective was sniffing out the problem as fast as possible. And Gretchen does that – a full hour ahead of that best available technology!

Her method? An urgent paw to the knee, followed by a bark. Gretchen takes no nonsense, delivering the testing kit to Stacey’s hand if her response is sluggish. If anything goes wrong Gretchen, as a trained service animal is taught to so do, sounds an alarm or alerts the nearest person to the danger. Stacey couldn’t ask for better care.

Stacey is the first South African to benefit from a Diabetic Assist Dog. Stacey Maguire’s dream is to start a facility to train more dogs to help diabetics like her. That’s something South Africa can get behind.

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Eleanor also added the following by way of background:

We found a phenomenal lady called Diane Marquette in Minnesota who agreed to train a dog for export – her first time for such an undertaking.

A three-year-old white Swiss Alsatian called Gretchen made the grade for the initial training after which Di started the diabetic training. In preparation, whenever Stacey felt unwell she spat into cotton-wool and put these samples into the freezer. When Stacey had collected a bundle she sent them via courier to Di who then trained Gretchen on Stacey’s scent.

This process took ten months. Then Stacey  flew to Minnesota to meet Gretchen, to be bonded with Gretchen, to be trained and, finally, to sit and pass a very stringent exam before being allowed to bring Gretchen back home. Ten days later we met them at Cape Town International, after twenty-one hours of flying for Stacey with Gretchen at her feet in the aeroplane. SA’s first DAD had landed!

In an email to me, Eleanor included:

Stacey and Gretchen have now been together for several years with their bond just strengthening and strengthening! Gretchen alerts Stacey continuously and in recent times has started alerting at night too. Thus even accounting for the fact that, as with all dogs, Gretchen sleeps at night coinciding, unfortunately, with when Stacey is most vulnerable to shocking lows, this fabulous dog maintains awareness of Stacey’s body scents during the night hours.

Stacey’s wish is to bring trainer Di of Scent Angels to Cape Town to train trainers, and then to roll this life-saving program out to fellow diabetics.

Diane Marquette

Eleanor also included the link to the website for Scent Angels. I shall pass on the link to this post to Diane Marquette with the request that she might allow me to share some more stories of these incredible dogs with you all.

John Zande

A stirrer of brain cells!

I have just finished reading John’s recently published book On the Problem of Good. I am writing a review of the book that, fingers crossed, I will publish on Friday. But many of you that are recent converts to this blog (you poor, lost souls!) will not remember my review of John’s first book and my reaction to that book when I was only just into it.

So, for both today and tomorrow I am republishing two blog posts. Today, one that was originally published on the 16th September, 2015, and tomorrow the post that was first published on 1st October, 2015.

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Of paradoxes, and headaches!

The interconnectedness of everything – even beyond our wildest imagination.

A while ago John Zande signed up to follow Learning from Dogs. Naturally, I went across to John’s blog to thank him. There I discovered that John is an animal lover and an author. For he states, referring to his book, that, “BUY IT. ALL PROCEEDS GO TO ANIMAL RESCUE AND SHELTER IN BRAZIL”. Fabulous!

John Zande cover_zpsz7wuq9cc

(I did buy the book, am about 20% through it and finding it very stimulating, – if you would like to buy it then click the image of the book on John’s home page.)

Anyway, a few days later we watched the BBC Horizon programme on multiple universes. Here’s how the BBC introduced the programme:

Which Universe Are We In?

Horizon, 2014-2015 Episode 17 of 19

Imagine a world where dinosaurs still walk the earth. A world where the Germans won World War II and you are president of the United States. Imagine a world where the laws of physics no longer apply and where infinite copies of you are playing out every storyline of your life.

It sounds like a plot stolen straight from Hollywood, but far from it. This is the multiverse.

Until very recently the whole idea of the multiverse was dismissed as a fantasy, but now this strangest of ideas is at the cutting edge of science.

And for a growing number of scientists, the multiverse is the only way we will ever truly make sense of the world we are in.

Horizon asks the question: Do multiple universes exist? And if so, which one are we actually in?

Horizon is always great to watch but this episode was incredibly stimulating and interesting. Later, in a exchange of comments to one of John’s posts, where I referred to that programme, John wrote:

The mulitverse is actually the more reasonable explanation for why there is something, and although I don’t understand the maths, the people who do say its simplistically beautiful. Matt Rave is an associate professor of physics and comments here regularly. He has a great book on it all, Why is There Anything?

raveThat lead me to purchasing Matthew Rave’s book that, likewise, is a most fascinating and unusual approach to this topic. His Amazon author’s page reveals that, “Dr. Matthew Rave is an assistant professor of physics at Western Carolina University, in the mountains of North Carolina. His research interests include interpretations of quantum mechanics, the geometric phase, solid state physics, and physics education.” Matthew Rave’s blogsite is here.

Matthew Rave’s book further illustrates the paradox, to my mind, that comes from thinking about why are we here, are we here and, if so, how do we know we are here?

So if that isn’t enough for you and me, then very recently The Conversation blogsite published the following from Geraint Lewis who is Professor of Astrophysics at the University of Sydney. It is republished here within the terms of The Conversation. Did I mention paradoxes and headaches!

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We are lucky to live in a universe made for us

Geraint Lewis, University of Sydney

To a human, the universe might seem like a very inhospitable place. In the vacuum of space, you would rapidly suffocate, while on the surface of a star you would be burnt to a crisp. As far as we know, all life is confined to a sliver of an atmosphere surrounding the rocky planet we inhabit.

But while the origin of life on Earth remains mysterious, there are bigger questions to answer. Namely: why do the laws of physics permit any life at all?

Hang on, the laws of physics? Surely they are a universal given and life just gets on with it?

But remember that the universe is built of fundamental pieces, particles and forces, which are the building blocks of everything we see around us. And we simply don’t know why these pieces have the properties they do.

There are many observational facts about our universe, such as electrons weighing almost nothing, while some of their quark cousins are thousands of times more massive. And gravity being incredibly weak compared to the immense forces that hold atomic nuclei together.

Why is our universe built this way? We just don’t know.

But what if…?

This means we can ask “what if” questions. What if the electron was massive and quarks were fleeting? What if electromagnetism was stronger than the nuclear strong force? If so, what would that universe be like?

Let’s consider carbon, an element forged in the hearts of massive stars, and an element essential to life as we know it.

Initial calculations of such stellar furnaces showed that they were apparently inefficient in making carbon. Then the British astronomer Fred Hoyle realised the carbon nucleus possesses a special property, a resonance, that enhanced the efficiency.

But if the strength of the strong nuclear force was only fractionally different, it would wipe out this property and leave the universe relatively devoid of carbon – and, thus, life.

The story doesn’t end there. Once carbon is made, it is ripe to be transmuted into heavier elements, particularly oxygen. It turns out that oxygen, due to the strength of the strong nuclear force, lacks the particular resonance properties that enhanced the efficiency of carbon creation.

This prevents all of the carbon being quickly consumed. The specific strength of the strong force has thus resulted in a universe with an almost equal mix of carbon and oxygen, a bonus for life on Earth.

Death of a universe

This is but a single example. We can play “what if” games with the properties of all of the fundamental bits of the universe. With each change we can ask, “What would the universe be like?”

The answers are quite stark. Straying just a little from the convivial conditions that we experience in our universe typically leads to a sterile cosmos.

This might be a bland universe, without the complexity required to store and process the information central to life. Or a universe that expands too quickly for matter to condense into stars, galaxies and planets. Or one that completely re-collapses again in a matter of moments after being born. Any complex life would be impossible!

The questions do not end there. In our universe, we live with the comfort of a certain mix of space and time, and a seemingly understandable mathematical framework that underpins science as we know it. Why is the universe so predictable and understandable? Would we be able to ask such a question if it wasn’t?

Our universe appears to balance on a knife-edge of stability. But why?

We appear to be very lucky to live in a universe that accommodates life. Zdenko Zivkovic/Flickr, CC BY

One of a multiverse

To some, science will simply fix it all. Perhaps, if we discover the “Theory of Everything”, uniting quantum mechanics with Einstein’s relativity, all of the relative masses and strengths of the fundamental pieces will be absolutely defined, with no mysteries remaining. To others, this is little more than wishful thinking.

Some seek solace in a creator, an omnipotent being that finely-tuned the properties of the universe to allow us to be here. But the move from the scientific into the supernatural leaves many uncomfortable.

There is, however, another possible solution, one guided by the murky and confused musings at the edge of science. Super-strings or M-theory (or whatever these will evolve into) suggest that the fundamental properties of the universe are not unique, but are somehow chosen by some cosmic roll of the dice when it was born.

This gives us a possible explanation of the seemingly special properties of the universe in which we live.

We are not the only universe, but just one in a semi-infinite sea of universes, each with their own peculiar set of physical properties, laws and particles, lifetimes and ultimately mathematical frameworks. As we have seen, the vast majority of these other universes in the overall multiverse are dead and sterile.

They only way we can exist to ask the question “why are we here?” is that we happen to find ourselves in a universe conducive to our very existence. In any other universe, we simply wouldn’t be around to wonder why we didn’t exist.

If the multiverse picture is correct, we have to accept that the fundamental properties of the universe were ultimately dished out in a game of cosmic roulette, a spin of the wheel that we appear to have won.

Thus we truly live in a fortunate universe.

The ConversationGeraint Lewis, Professor of Astrophysics, University of Sydney

This article was originally published on The Conversation. Read the original article.

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How to follow that, eh?

Let me give way to Hariod Brawn and part of an extensive comment she left back then:

John Zande is most certainly one of the most thoughtful, perceptive, well-informed and sharp-witted bloggers I have ever come across, and I wish him well with his book, which by the way, appears so far to have been met only with a deluge of 5-star reviews on Amazon. I daresay that you and I will both lengthen that list.

Here! Here!

The Cave of Crystal Giants

This will take us away from the daily beat of life!

On the 18th. February the BBC News website carried an article that I found incredible. It was the story of Naica’s crystal caves in Mexico.

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Naica’s crystal caves hold long-dormant life

By Jonathan Amos, BBC Science Correspondent, Boston, 18 February 2017.

The caves were discovered by miners 100 years ago
The caves were discovered by miners 100 years ago. Picture credit: Penelope J. Boston

It is a remarkable discovery in an amazing place.

Scientists have extracted long-dormant microbes from inside the famous giant crystals of the Naica mountain caves in Mexico – and revived them. [Ed: my emphasis]

The organisms were likely to have been encased in the striking shafts of gypsum at least 10,000 years ago, and possibly up to 50,000 years ago.

It is another demonstration of the ability of life to adapt and cope in the most hostile of environments.

“Other people have made longer-term claims for the antiquity of organisms that were still alive, but in this case these organisms are all very extraordinary – they are not very closely related to anything in the known genetic databases,” said Dr Penelope Boston.

The new director of Nasa’s Astrobiology Institute in Moffett Field, California, described her findings here at the annual meeting of the American Association for the Advancement of Science (AAAS).

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I was delighted to find more details in many other places on the ‘web’.

Such as this one on the National Geographic website:

By Victoria Jaggard

PUBLISHED February 17, 2017

Boston, Massachusetts

Creatures that thrive on iron, sulfur, and other chemicals have been found trapped inside giant crystals deep in a Mexican cave. The microbial life-forms are most likely new to science, and if the researchers who found them are correct, the organisms are still active even though they have been slumbering for tens of thousands of years.

If verified, the discovery adds to evidence that microbial life on Earth can endure harsher conditions in isolated places than scientists previously thought possible. (See “Life Found Deep Under Antarctic Ice for First Time?”)

“These organisms have been dormant but viable for geologically significant periods of time, and they can be released due to other geological processes,” says NASA Astrobiology Institute director Penelope Boston, who announced the find today at a meeting of the American Association for the Advancement of Science. “This has profound effects on how we try to understand the evolutionary history of microbial life on this planet.”

Then there’s another article on that NatGeo website: (Apologies for some duplication in the message.)

By Neil Shea, National Geographic Staff
In a nearly empty cantina in a dark desert town, the short, drunk man makes his pitch. Beside him on the billiards table sits a chunk of rock the size of home plate. Dozens of purple and white crystals push up from it like shards of glass. “Yours for $300,” he says. “No? One hundred. A steal!” The three or four other patrons glance past their beers, thinking it over: Should they offer their crystals too? Rock dust on the green felt, cowboy ballads on the jukebox. Above the bar, a sign reads, “Happy Hour: 8 a.m. to 9 p.m.”

This remote part of northern Mexico, an hour or so south of Chihuahua, is famous for crystals, and paychecks at the local lead and silver mine, where almost everyone works, are meager enough to inspire a black market. “Thirty dollars.” He leans in. “Ten.” It’s hard to take him seriously. Earlier in the day, in a cave deep below the bar, I crawled among the world’s largest crystals, a forest of them, broad and thick, some more than 30 feet long and half a million years old. So clear, so luminous, they seemed extraterrestrial. They make the chunk on the pool table seem dull as a paperweight.

Nothing compares with the giants found in Cueva de los Cristales, or Cave of Crystals. The limestone cavern and its glittering beams were discovered in 2000 by a pair of brothers drilling nearly a thousand feet below ground in the Naica mine, one of Mexico’s most productive, yielding tons of lead and silver each year. The brothers were astonished by their find, but it was not without precedent. The geologic processes that create lead and silver also provide raw materials for crystals, and at Naica, miners had hammered into chambers of impressive, though much smaller, crystals before. But as news spread of the massive crystals’ discovery, the question confronting scientists became: How did they grow so big?

It takes 20 minutes to get to the cave entrance by van through a winding mine shaft. A screen drops from the van’s ceiling and Michael Jackson videos play, a feature designed to entertain visitors as they descend into darkness and heat. In many caves and mines the temperature remains constant and cool, but the Naica mine gets hotter with depth because it lies above an intrusion of magma about a mile below the surface. Within the cave itself, the temperature leaps to 112 degrees Fahrenheit with 90 to 100 percent humidity—hot enough that each visit carries the risk of heatstroke. By the time we reach the entrance, everyone glistens with sweat.

That article continues here.
Finally, lose yourself in this video. (If the voice doesn’t get to you!)

How to close today’s post?

Both by embracing the power of the natural order of things, life and death, and by reminding us all that there are in the order of over two billion stars in this universe.

That universe must be teeming with life, current and dormant, and the day when we truly confirm that will put everything into perspective!

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Talk about synchronicity!

For yesterday, around 10am PST, the BBC News website carried this big news item: Earliest evidence of life on Earth ‘found’.

Here’s how that article opens:

Earliest evidence of life on Earth ‘found’

By Pallab Ghosh Science correspondent, BBC News
Scientists have discovered what they say could be fossils of some of the earliest living organisms on Earth.
They are represented by tiny filaments, knobs and tubes in Canadian rocks dated to be up to 4.28 billion years old.
That is a time not long after the planet’s formation and hundreds of millions of years before what is currently accepted as evidence for the most ancient life yet found on Earth.

The researchers report their investigation in the journal Nature.

As with all such claims about ancient life, the study is contentious. But the team believes it can answer any doubts.

The scientists’ putative microbes from Quebec are one-tenth the width of a human hair and contain significant quantities of haematite – a form of iron oxide or “rust”.

Matthew Dodd, who analysed the structures at University College London, UK, claimed the discovery would shed new light on the origins of life.

Do read the full article including viewing some wonderful photographs.

Now this is talent!

Just be enthralled by Marc Métral and his talking dog Wendy.

Jean sent me the link to the following that had, in turn, been sent to her.

It features the show on ITV in the UK, Britain’s Got Talent, that has been running for many years. Verified on the BGT website by the 10 Years link:

Some of our favourite acts from the past ten years took to the BGT stage to pay tribute to a decade of finding amazing talent!

But the fun doesn’t end there. We’re on the lookout for even more incredible talent and we’re coming to a town near you soon! Find out where we’re holding auditions and apply now for the new series of Britain’s Got Talent!

Anyway, without further ado just watch this act. It’s not just the judges that are wowed; you will be as well!

Marc Métral and his talking dog Wendy wow the judges|Britain’s Got Talent 2015

Published on Apr 11, 2015

The Judges are left open-mouthed when Marc Métral introduces his talking dog Miss Wendy.
“Congratulations, in the nine years of doing this show, Simon has said he wanted a dog that could meow or sing, and you did both, incredible,” says Amanda.
Simon is totally smitten!

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Follow That!

Our best friend is really here to help

The most incredibly relationship we humans have ever had with an animal.

Tomorrow, I am going to repeat a post that first appeared on Learning from Dogs seven years ago. A beautiful documentary explaining in clear, scientific ways how important has been the relationship between the dog and humans.

But for today, as a ‘warm up’ to tomorrow’s post, I wanted to share an essay that appeared on The Conversation blogsite a little over a week ago and is republished within the terms of The Conversation site.

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How man’s best friend is helping cancer treatment

By    Professor of Veterinary Medicine, Colorado State University

February 2, 2017
The author, center, and Dr. Anna Conti, left, and student Kelsey Parrish with Conti’s Basset hound, Picasso, who had surgery for cancer. Via Colorado State University. William Cotton/CSU Photography, Author provided
The author, center, and Dr. Anna Conti, left, and student Kelsey Parrish with Conti’s Basset hound, Picasso, who had surgery for cancer. Via Colorado State University. William Cotton/CSU Photography, Author provided

“A person can learn a lot from a dog, even a loopy one like ours. Marley taught me about living each day with unbridled exuberance and joy, about seizing the moment and following your heart… Mostly, he taught me about friendship and selflessness and, above all else, unwavering loyalty.”

― John Grogan, “Marley and Me: Life and Love With the World’s Worst Dog.”

Isn’t it true? We learn so much from our dogs. But beyond what man’s best friend can teach us about enjoying life, they share something else with us. Cancer diagnoses in dogs are on the rise, as are cancer diagnoses in people. In fact, canine cancer is the leading cause of death in pets over the age of 10 years.

This confluence, it turns out, can be beneficial to cancer research. A field of study known as “comparative oncology” has recently emerged as a promising means to help cure cancer. Comparative oncology researchers study the similarities between naturally occurring cancers in pets and cancers in people in order to provide clues to treat cancer more effectively.

In fact, phase 1 and 2 clinical trials in comparative oncology are underway at 22 sites across the country, including Colorado State University, where I conduct research and am a surgical oncologist for animals.

Research in this field, involving veterinarians, physicians, cancer specialists and basic scientists, is leading to improved human health and more rapid access to effective cancer treatment than has been previously possible through traditional cancer research approaches.

More like your dog than you know

Man and his best friend. From www.shutterstock.com
Man and his best friend. From http://www.shutterstock.com

As a species, dogs have strong physiologic and genetic similarities to people, much more so than mice, who do not typically live long enough for us to know whether they naturally get cancer. We do know that some rodent species, such as pet rats, can get cancer, but predators typically end a field mouse’s life while it is still young. The laboratory mice typically used by scientists are injected with cancer rather than it occurring naturally in their bodies.

Just as scientists officially mapped the human genome, or the complete set of genetic instructions, in 2003, scientists decoded the canine genome. They discovered that dogs have greater than 80 percent genetic similarity to humans, versus only 67 percent for mice.

In addition, cancers such as bone cancer, lymphoma and bladder cancer that spontaneously arise in pet dogs are microscopically and molecularly identical to cancers in people. Many of the genetic mutations that drive cells to become cancerous in people are the same mutations that cause cancer in dogs. In fact, when viewed under a microscope, it is impossible to distinguish between a tumor from a human and a dog.

In addition, dogs provide a large and varied population to study, important in the study of medicine. Individual dogs who develop cancer are as different from one another as are humans. Whereas laboratory mice are essentially identical twins to each other and live in a highly regulated environment, the variation among different dog breeds, home environments, diet and overall lifestyle translate into a population diversity very similar to that in humans.

Today, most pet dogs receive high-quality health care into old age and dog owners are highly motivated to seek out improved options for the management of cancer in their companions, and are also motivated to minimize side effects.

Similarities in response to treatment, too

Picasso at the James L. Voss Veterinary Teaching Hospital, Colorado State University. Author provided., Author provided
Picasso at the James L. Voss Veterinary Teaching Hospital, Colorado State University. Author provided., Author provided.

This genetic diversity and sharing of similar DNA, physiology, microscopic structure and molecular features between dogs and humans has presented cancer researchers with a key opportunity. Dogs not only develop similar types of cancers as humans, but their cancer responds to treatments in similar ways.

This means that new cancer treatments first shown to be effective in canine cancers can frequently be predicted to have a similar benefit in human cancer patients. As a result, researchers now recognize that new drug trials in dogs with cancer will result in therapeutic discoveries that are highly “translatable”; that is, more likely to predict “real-life” medical responses in human cancer patients.

By studying how cancer responds in dogs, scientists are gaining a better understanding of how new cancer drugs not only treat the cancer but also influence the patient’s overall quality of life during treatment. This benefits dog owners, by providing access to promising new cancer treatments for their pets with cancer, and benefits human cancer patients by providing a rapid way to collect crucial data needed for FDA approval.

Dogs with cancer are helping kids

For example, a bone cancer known as osteosarcoma is so similar between dogs and people that

The author performing surgery on a dog. Author provided. Colorado State University., Author provided.
The author performing surgery on a dog. Author provided. Colorado State University., Author provided.

intensive research in canine osteosarcoma has led to several breakthroughs in treating osteosarcoma in children. Limb-saving surgical techniques for safe and effective reconstruction following bone tumor surgery in dogs are now the standard of care in children following bone tumor surgery.

More recently, a form of immunotherapy was shown to drastically improve survival in dogs with bone cancer by delaying or altogether preventing spread of the cancer to the lungs. As a result of the success in dogs, the FDA granted fast-track status to the same treatment for use in humans last April.

Fast-tracking was developed by the FDA to support accelerated approval for promising treatments, especially for serious and life-threatening conditions. A clinical trial in children with osteosarcoma is scheduled to begin this year at multiple pediatric cancer centers throughout the United States.

These types of discoveries demonstrate that our furry companions have a crucial role in teaching us new ways to help all victims in the war against cancer – with two legs or four.

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As I said in my introduction, more on this theme tomorrow.

What a fabulous relationship!