Tag: Michelle Roberts

Prostate drug may slow Parkinson’s disease – BBC News

A very interesting development.

I was chatting to my very old friend, as in the number of years, Richard Maugham yesterday and shortly after the call he sent me an email with a link to a recent item on the BBC News website.

Most of you regulars know that Jeannie was diagnosed with Parkinson’s disease (PD) in December, 2015 and coincidentally at the same time Richard was also diagnosed with PD.

I’m sure there are a few who read this blog that either have PD of know or someone who has it.

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Prostate drug may slow Parkinson’s disease

By Michelle Roberts,
Health editor, BBC News online

17th September, 2019

A drug used to treat enlarged prostates may be a powerful medicine against Parkinson’s disease, according to an international team of scientists.

Terazosin helps ease benign prostatic hyperplasia (BPH) by relaxing the muscles of the bladder and prostate.

But researchers believe it has another beneficial action, on brain cells damaged by Parkinson’s.

They say the drug might slow Parkinson’s progression – something that is not possible currently.

Cell death

They studied thousands of patients with both BPH and Parkinson’s.

Their findings, published in the Journal of Clinical Investigation, suggest the alpha-blocker drug protects brain cells from destruction.

Parkinson’s is a progressive condition affecting the brain, for which there is currently no cure.

Existing Parkinson’s treatments can help with some of the symptoms but can’t slow or reverse the loss of neurons that occurs with the disease.

Terazosin may help by activating an enzyme called PGK1 to prevent this brain cell death, the researchers, from the University of Iowa, in the US and the Beijing Institute for Brain Disorders, China, say.

Clinical trials

When they tested the drug in rodents it appeared to slow or stop the loss of nerve cells.

To begin assessing if the drug might have the same effect in people, they searched the medical records of millions of US patients to identify men with BPH and Parkinson’s.

They studied 2,880 Parkinson’s patients taking terazosin or similar drugs that target PGK1 and a comparison group of 15,409 Parkinson’s patients taking a different treatment for BPH that had no action on PGK1.

Patients on the drugs targeting PGK1 appeared to fare better in terms of Parkinson’s disease symptoms and progression, which the researchers say warrants more study in clinical trials, which they plan to begin this year.

‘Exciting area’

Lead researcher Dr Michael Welsh says while it is premature to talk about a cure, the findings have the potential to change the lives of people with Parkinson’s.

“Today, we have zero treatments that change the progressive course of this neurodegenerative disease,” she says.

“That’s a terrible state, because as our population ages Parkinson’s disease is going to become increasingly common.

“So, this is really an exciting area of research.”

‘Disease modifying’

Given that terazosin has a proven track record for treating BPH, he says, getting it approved and “repurposed” as a Parkinson’s drug should be achievable if the clinical trials go well.

The trials, which will take a few years, will compare the drug with a placebo to make sure it is safe and effective in Parkinson’s.

Co-researcher Dr Nandakumar Narayanan, who treats patients with Parkinson’s disease said: “We need these randomised controlled trials to prove that these drugs really are disease modifying.

“If they are, that would be a great thing.”

Prof David Dexter from Parkinson’s UK said: “These exciting results show that terazosin may have hidden potential for slowing the progression of Parkinson’s, something that is desperately needed to help people live well for longer.

“While it is early days, both animal models and studies looking at people who already take the drug show promising signs that need to be investigated further.”

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I have now written to the Journal of Clinical Investigation, (JCI).

Interestingly, if one goes to the website of the JCI then one reads the following on the ‘About’ page:

The Journal of Clinical Investigation is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine.

The JCI was founded in 1924 and is published by the ASCI, a nonprofit honor organization of physician-scientists incorporated in 1908. See the JCI’s Wikipedia entry for detailed information.

It’s a small step forward!

Meditating.

A guest post from Sue Dreamwalker.

Last Monday, the post on Learning from Dogs was called Growing old!!

The essence of that post was to report on the following:

That’s why a recent item on the BBC News website jumped off the page at me.  It was an article called: Health kick ‘reverses cell ageing’ written by Michelle Roberts, Health editor, BBC News online.  Here is how the article opened:

Going on a health kick reverses ageing at the cellular level, researchers say.

The University of California team says it has found the first evidence a strict regime of exercise, diet and meditation can have such an effect.

But experts say although the study in Lancet Oncology is intriguing, it is too early to draw any firm conclusions.

The study looked at just 35 men with prostate cancer. Those who changed their lifestyle had demonstrably younger cells in genetic terms.

The full article should be read, by the way, because it covers much more than this opening paragraph.

Anyway, one of the comments to that post was left by Sue, of Sue Dreamwalker, Here is what she wrote:

Great information and learning to Meditate even for a few minutes helps heal and relax.. Dogs have it right…. No stress!

I wrote a complete exercise I used a lot both for myself and within my circle I used to run… Hope you enjoy as you take your roots down into the earth after bringing in the Light….
you can find it here http://wp.me/p16xW7-37

Namaste! :-)

I then asked Sue if I could republish her guidance on meditation as a guest post.  Sue kindly agreed.  Here it is.

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A Meditation For My Friends

by Sue Dreamwalker

Meditation-1

Meditation.

Some Friends have been asking about Meditation and relaxation techniques, so I have put you a very simple little meditation here for starters.

You can buy books on meditation and read different techniques until your eyes pop out of your head, and you can find plenty about meditation on web sites too.  I always say there is no right or wrong way to Meditate. To meditate means finding that quiet place within your own mind, finding that peace and space to be at one with yourself.

When people say empty your mind, this is near enough impossible, as you will always have a train of thought that will pop in at times. So this is why we use the Breath.

The breath is used to bring your concentration back, so focusing on your breath may be one way in which you can stop the hum-drum of your thoughts that chatter away inside your head.

First you need to ensure you’re not going to be disturbed, so switch of the phone, find a comfortable chair, in a quiet room, and relax.  If you lie down you may find that you drift asleep, that’s ok also for that shows you have relaxed.  But preferably sit upright with your feet slightly apart and have them touching the ground. Take deep breaths breathing in and out through the nose, and close your eyes.

This is one of the meditations I do regularly.  It may seem long to read, but once you have it in your mind it will only take you 10 minutes to do. Read it through a couple of times until you have it clear in your mind, and then have a go.

meditation

Relax and take some nice deep breaths  breathing deeply and evenly, try to breath in to the count of five, hold for a few seconds and then breath out long and slow, Feel your breath rise from your solar plexus your stomach and feel your diaphragm rise and fall.

Do this for a few minutes until you feel comfortable with breathing this way. (Many of us do not breathe deep enough, so this may at first feel uncomfortable, but try not to force it, just try to get your breath into a natural rhythm).

One your breath is comfortable I want you to imagine a beautiful White light coming down in a column from up above  your head.  Almost like a search light in a darkened room.

As you breath in, I want you to breathe in this light. Imagine that it is flowing down inside your head through your crown, and it passes behind your eyes, relaxing your eyes. It then passes down over your throat, relaxing your throat.

You feel this Light which has healing properties cascading across your shoulders, relaxing your shoulders, taking all the burdens of the day with it.  You now see and feel this warm Light travel down your arms into your forearms relaxing your muscles as it goes, now it’s travelling into your finger tips, and your arms now feel heavy and relaxed.

You see the Light now travel through from your throat, down into your heart centre, feel the beat of your heart, and see the light now filling your heart and as it beats see the light dispersing throughout your veins into your whole being,

See the light travelling into your stomach relaxing your stomach muscles, down your thighs relaxing your thighs into your calves, relaxing your calves, and see the light now going into your feet relaxing your toes and feet.

And all the while you are breathing deeply and evenly, relaxing more and more.

meditation-2

Now you are relaxed and are full of healing light, I want you to now see that light coming out of the soles of your feet, as if they were roots from a tree. See these roots going down from your feet into Mother Earth, going down through the rocks, twisting and turning as they go deeper and deeper, and as they travel deeper so too you are feeling more and more relaxed.

You now see an underground cavern, with an underground pool, your roots of light emerge in the ceiling of this cavern, and illuminate it like the lights of a chandelier.

And as the light illuminates the Cavern you now see you are stood in a beautiful Crystal Cavern, The Light reflects the many luminous rainbow colours from the hundreds of giant crystals.. See the rainbow of pastel colours dance around the cavern reflection on the underground pool.

Now you can choose any colour you see, for whatever colour you choose this colour will intuitively be the right healing colour for your needs at this moment in time.

So once you see the colour you are attracted to, allow your roots to wrap themselves around that crystal, and as you breathe deeply in, see now that your roots have now turned into hollow straws, for you will now be able to breathe up that colour through your roots and as you do so, retract your roots back up through Mother Earth, breathe that  colour into your feet, feel the warmth of the healing.

Now draw it back up through your calves, up through your thighs, into your solar plexus. Breathing deeply and evenly. Feel the warmth of healing relax and heal all your worries and anxieties, breath it up into your lungs, into your heart, down your arms and into your fingers, see how relaxed and refreshed you now feel, see this colour cleansing your entire being taking with it all the debris that you have collected, all the negative thoughts, flushing you clean.

See this colour now rise and come up through your throat, see it helping you release all the words you have spoken in haste, and all the words you hold back, see them all now flow up past your eyes, helping you see that you are a Being of Light and whole and free, see that colour now rise out through the top of your head, see it cascading out into the Universe Like a fountain, and as it does so see it explode into a thousand stars, taking all your problems and negative debris with it, and know that God and the Universe will disperse this energy as it sees fit,

Give thanks to Mother Earth for her healing energy, and see the top of your head close and seal in your new vibration, and feel yourself glowing from within,

Slowly bring your awareness back to yourself sat in the chair, and open your eyes.

Sit for a moment or two and take a sip of water.

Know that you can go to your crystal cavern at any time for healing.


Soulfly

Hope you relax and Enjoy.

x Dreamwalker x

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And if you want any encouragement to find that deep, peaceful place, then just breath in this picture of young Cleo letting the world go by!

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Growing old!!

Are there options?  Are there decisions to be made?

Of the two certainties in life, one of them is pretty stark: death!  (The other certainty is taxes, by the way!)

So one could legitimately argue that if death is ‘non-negotiable’ then it’s not even worth spending a moment dwelling on it.  And certainly not worth the time and effort in writing about it!

But, of course, this misses a very big point.  That is that doing all we can to improve our quality of life, especially in the Autumn of our lives, is very important.

That’s why a recent item on the BBC News website jumped off the page at me.  It was an article called: Health kick ‘reverses cell ageing’ written by Michelle Roberts, Health editor, BBC News online.  Here is how the article opened:

Going on a health kick reverses ageing at the cellular level, researchers say.

The University of California team says it has found the first evidence a strict regime of exercise, diet and meditation can have such an effect.

But experts say although the study in Lancet Oncology is intriguing, it is too early to draw any firm conclusions.

The study looked at just 35 men with prostate cancer. Those who changed their lifestyle had demonstrably younger cells in genetic terms.

“Reverses ageing”!  How on earth can that work?

The researchers saw visible cellular changes in the group of 10 men who switched to a vegetarian diet and stuck to a recommended timetable of exercise and stress-busting meditation and yoga.

The changes related to protective caps at the end of our chromosomes, called telomeres.

Their role is to safeguard the end of the chromosome and to prevent the loss of genetic information during cell division.

As we age and our cells divide, our telomeres get shorter – their structural integrity weakens, which can tell cells to stop dividing and die.

Researchers have been questioning whether this process might be inevitable or something that could be halted or even reversed.

The latest work by Prof Dean Ornish and colleagues suggests telomeres can be lengthened, given the right encouragement.

Now if you, like me, are noticing some of the rather frustrating aspects of ageing, then this one piece of science research could turn out to be invaluable.  But best not to get too carried away just now, as the BBC article underlines:

Prof Ornish said: “The implications of this relatively small pilot study may go beyond men with prostate cancer. If validated by large-scale randomised controlled trials, these comprehensive lifestyle changes may significantly reduce the risk of a wide variety of diseases and premature mortality.

“Our genes, and our telomeres, are a predisposition, but they are not necessarily our fate.”

Dr Lyn Cox, a biochemistry expert at Oxford University in the UK, said it was not possible to draw any conclusions from the research, but added: “Overall, though, the findings of this paper that changes in lifestyle can have a positive effect on markers of ageing support the calls for adoption of and adherence to healthier lifestyles.”

Dr Tom Vulliamy, senior lecturer in Molecular Biology at Queen Mary University of London, said: “It is really important to highlight that this is a small pilot study.

Nevertheless, here’s how the article ends:

But past work has shown that people who lead a sedentary lifestyle can experience accelerated cellular ageing in the form of more rapid shortening of their telomeres.

All of which rather embarrassingly reminds me that back on the 6th August, in a post called The habit of doing nothing, I set out Leo Babauta’s  ‘How To Meditate‘ guide.  Then, frankly, ignored it!  So to me and all you other readers who would like to chill out like your dog, here’s that guide again.

How to Do It Daily

There are lots and lots of ways to meditate. But our concern is not to find a perfect form of meditation — it’s to form the daily habit of meditation. And so our method will be as simple as possible.

1. Commit to just 2 minutes a day. Start simply if you want the habit to stick. You can do it for 5 minutes if you feel good about it, but all you’re committing to is 2 minutes each day.

2. Pick a time and trigger. Not an exact time of day, but a general time, like morning when you wake up, or during your lunch hour. The trigger should be something you already do regularly, like drink your first cup of coffee, brush your teeth, have lunch, or arrive home from work.

3. Find a quiet spot. Sometimes early morning is best, before others in your house might be awake and making lots of noise. Others might find a spot in a park or on the beach or some other soothing setting. It really doesn’t matter where — as long as you can sit without being bothered for a few minutes. A few people walking by your park bench is fine.

4. Sit comfortably. Don’t fuss too much about how you sit, what you wear, what you sit on, etc. I personally like to sit on a pillow on the floor, with my back leaning against a wall, because I’m very inflexible. Others who can sit cross-legged comfortably might do that instead. Still others can sit on a chair or couch if sitting on the floor is uncomfortable. Zen practitioners often use a zafu, a round cushion filled with kapok or buckwheat. Don’t go out and buy one if you don’t already have one. Any cushion or pillow will do, and some people can sit on a bare floor comfortably.

5. Start with just 2 minutes. This is really important. Most people will think they can meditate for 15-30 minutes, and they can. But this is not a test of how strong you are at staying in meditation — we are trying to form a longer-lasting habit. And to do that, we want to start with just a two minutes. You’ll find it much easier to start this way, and forming a habit with a small start like this is a method much more likely to succeed. You can expand to 5-7 minutes if you can do it for 7 straight days, then 10 minutes if you can do it for 14 straight days, then 15 minutes if you can stick to it for 21 straight days, and 20 if you can do a full month.

6. Focus on your breath. As you breathe in, follow your breath in through your nostrils, then into your throat, then into your lungs and belly. Sit straight, keep your eyes open but looking at the ground and with a soft focus. If you want to close your eyes, that’s fine. As you breathe out, follow your breath out back into the world. If it helps, count … one breath in, two breath out, three breath in, four breath out … when you get to 10, start over. If you lose track, start over. If you find your mind wandering (and you will), just pay attention to your mind wandering, then bring it gently back to your breath. Repeat this process for the few minutes you meditate. You won’t be very good at it at first, most likely, but you’ll get better with practice.

And that’s it. It’s a very simple practice, but you want to do it for 2 minutes, every day, after the same trigger each day. Do this for a month and you’ll have a daily meditation habit.

Yet again, dogs offer us a great example.

For here’s a photograph of Pharaoh that I took just a few moments ago showing him deep in meditation behind my chair!

Demonstrating the art of doing nothing!
Demonstrating the art of doing nothing!

Not so daft an idea!

Is there a link between anxiety and dementia?

Before going to a recent BBC report about this important subject, let me offer a personal anecdote.

A couple of months ago I had cause to be seen by a neurologist.  I wanted to get a professional opinion as to whether a degree of forgetfulness that I was experiencing was normal for a person of my age (68 next birthday).  Dr. G. not only confirmed that there was absolutely no sign of dementia but that my forgetfulness was perfectly normal for someone of my age who had been through some major life changes in the last few years.

Dr. G. stressed (probably not the best word but you know what I mean!) that me worrying about forgetting stuff and the resulting anxiety was a self-feeding issue.  I had to stop being anxious.  Indeed, Dr. G. said the following (and this I haven’t forgotten!):

Anxiety is the killer of good bodies and the killer of good brains!

So with those words ringing in your ears, have a read of this recent report from the BBC News website.

Role of stress in dementia investigated

By Michelle Roberts, Health editor, BBC News online

UK experts are to begin a study to find out if stress can trigger dementia.

The investigation, funded by the Alzheimer’s Society, will monitor 140 people with mild cognitive impairment or “pre-dementia” and look at how stress affects their condition.

The researchers will take blood and saliva samples at six-monthly intervals over the 18 months of the study to measure biological markers of stress.

They hope their work will reveal ways to prevent dementia.

The results could offer clues to new treatments or better ways of managing the condition, they say.

Dementia triggers

People who have mild cognitive impairment are at an increased risk of going on to develop dementia – although some will remain stable and others may improve.

And past work suggests mid-life stress may increase a person’s risk of Alzheimer’s disease.

A Swedish study that followed nearly 1,500 women for a period of 35 years found the risk of dementia was about 65% higher in women who reported repeated periods of stress in middle age than in those who did not.

Scottish scientists, who have done studies in animals, believe the link may be down to hormones the body releases in response to stress which interfere with brain function.

Prof Clive Holmes, from the University of Southampton, who will lead the study, said: “All of us go through stressful events. We are looking to understand how these may become a risk factor for the development of Alzheimer’s.

“Something such as bereavement or a traumatic experience – possibly even moving home – are also potential factors.

“This is the first stage in developing ways in which to intervene with psychological or drug-based treatments to fight the disease.

“We are looking at two aspects of stress relief – physical and psychological – and the body’s response to that experience.”

Dr Simon Ridley, of Alzheimer’s Research UK, said: “We welcome any research that could shed new light on Alzheimer’s disease and other causes of dementia.

“Understanding the risk factors for Alzheimer’s could provide one piece of the puzzle we need to take us closer to a treatment that could stop the disease in its tracks.”

More on This Story

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Your guide to reducing the risk of dementia

Stress linked to OAP memory loss

Dementia: Your stories

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Finally, let me leave you with this.