I am reading the latest issue of Science, the magazine put out by AAAS – the American Academy for the Advancement of Science. One of the news items in that issue is entitled Massive study of dog aging likely to lose funding.
One reads, in part, a remark by biogerontologist, Steve Austed of the University of Alabama at Birmingham: “It was going to be the most informative study of aging that was not done in humans.“
The project has a website, Dog Aging Project, from which one finds, under Project Details:
Science’s Best Friend
DOGS & HUMANS
Studying aging in humans is challenging and expensive, but dogs truly are science’s best friends. Even though they age more rapidly than humans, they experience the same diseases of aging, they are genetically diverse, and they share our environment. By studying aging in dogs, we can more quickly expand our knowledge of the aging process not just in dogs but in humans too!
It is a great shame that the likelihood is that the project will cease.
I was just idly browsing dog websites a couple of days ago and came across the Dog Aging Project. As their About page reports:
The goal of the Dog Aging Project is to understand how genes, lifestyle, and environment influence aging. We want to use that information to help pets and people increase healthspan, the period of life spent free from disease.
I have taken the liberty of sharing one of their blog posts with you (I can’t see that isn’t allowed!)
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Longer, healthier lives. Together.
Dog and Human Genetics: Similarity and Difference
July 26th, 2022
Your pup may be your “fur baby,” but how similar are you genetically? You may be surprised!
Did you know that dogs and people share over 17,000 special genes called orthologs? Each pair of orthologs is derived from the same common ancestor via vertical descent (speciation) and they tend to have similar functions. They are one of the main reasons why your pup is such an invaluable comparative animal model for studying human health. In fact, humans and dogs have numerous similarities even in those parts of the genome that aren’t genes (the noncoding part of the genome). When it comes to better understanding human health, your pup is our best friend!
Sometimes, the effects of a gene are identical between dogs and people. For example, the same version of EPAS1, a gene triggered by low-oxygen conditions, is shared by people living in the Tibetan Plateau and the dog lineages that developed there. Genetic changes in this gene have taken place to help kickstart the body’s responses to hypoxia, or low oxygen levels, at high altitudes.
In other cases, the effects of a gene may be similar but not identical. For instance, the gene SCN3A is important to brain function and affects the development of speech. In children, mutations in SCN3A have been reported to cause disorders like epilepsy. But in dogs, genetic changes near the canine ortholog of SCN3A are associated with the frequency of howling in dogs.[1] The functions of this gene seem distinct (speech versus howling) but related!
For other health conditions shared by dogs and people, the same genes may not be responsible, but that doesn’t mean that research on those conditions in dogs isn’t helpful for humans! By learning more about how a dog’s genes are connected with a shared health condition, we can investigate the biological mechanisms involved and potentially make links to human health.
For example, people long suggested that narcolepsy might be a disease of the immune system: an autoimmune attack that causes daytime drowsiness and sudden sleep. In human studies, it was difficult to confirm the immune system link. It wasn’t until 1999[2] that this connection was discovered in a lineage of Doberman pinscher dogs. The researchers discovered a gene that is involved in the interface between the nervous system and immune system.
Finally, you and your pup share more than just genetics. Your environments are also very similar! You sleep in the same house—maybe even the same bed!—go on walks together, and breathe the same air. Interactions between these environmental variables and your genetics (called gene by environment interactions) can have an important impact on health. For example, smoking is well known to increase risk of bladder cancer in humans[3], but it is still unknown how secondhand smoke affects risk of bladder cancer in dogs.[4]
Data from the Dog Aging Project should help us answer important questions like these!
2. Ling Lin et al. 1999. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene. Cell 98 (3): 365-376. https://doi.org/10.1016/S0092-8674(00)81965-0
3. JD Figueroa et al. 2014. Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis 35 (8):1737-44. https://pubmed.ncbi.nlm.nih.gov/24662972/
Here’s an anti-aging project that we all wish for a successful outcome.
Despite the fact that one of the very important items that we learn from dogs is the certainty of death, there is not a single dog carer who doesn’t want them to live much longer lives.
Today’s post is the republication of a recent science report over on Mother Nature Network concerning a drug, rapamycin, that is hoped may give our wonderful dogs several more healthy years of life. As always, republished within the generous terms of MNN.
We wish the scientists much luck in achieving this outcome, without any deleterious side effects.
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Anti-aging project aims to extend dogs’ life spans
Researchers hope a drug called rapamycin can give dogs several more healthy years of life.
By: Russell McLendon, December 4, 2015,
Although some dogs have lived as long as 29 years, canine life spans are typically closer to half that length. (Photo: Shutterstock)
Living with a dog can help humans in lots of ways, from reducing stress and anxiety to lifting our spirits and making us laugh. Yet despite the abundance of benefits dogs offer, they also come with a notable drawback: Their life spans are much shorter than ours, forcing us to deal with the sadness of their deaths every 15 years or so.
Grieving for our dogs is just part of life, and in the big picture, it’s a small price to pay. But according to researchers at the University of Washington (UW), there may be a way to help our best friends stay with us — and stay healthy — a little longer.
Dog aging varies widely by size and breed, with smaller dogs typically maturing more quickly, yet also living a few years longer on average. It’s also common for mutts to outlive purebred dogs, thanks to the perks of higher genetic diversity. But while almost any dog is considered elderly by age 15, some have been known to nearly double their expected life spans — including Bluey, an Australian cattle dog who famously lived to see his 29th birthday last century.
And now researchers at UW’s Dog Aging Project (DAP) are working to bring similar longevity to canines of all kinds. In addition to performing “the first nationwide, large-scale longitudinal study of aging in pet dogs,” this project involves efforts to improve dogs’ “healthy life span” via therapies that already work in lab settings.
“To be clear, our goal is to extend the period of life in which dogs are healthy, not prolong the already difficult older years,” the project’s website explains. “Imagine what you could do with an additional two to five years with your beloved pet in the prime of his or her life. This is within our reach today.”
If it pans out, this may also aid ongoing research into extending the lives of other animals, including humans. But for now, the therapy is focused on dogs.
Researchers think rapamycin might increase a dog’s healthy life span by up to 5 years. (Photo: Shutterstock)
Namely, they’re testing the FDA-approved drug rapamycin (aka sirolimus) on middle-aged dogs. High doses of rapamycin are already used in humans to fight cancer and prevent organ-transplant rejection, but at low doses, it has also been shown to slow aging and extend life span in several animals with few or no side effects. In mice, for example, the immunosuppressant can lengthen lives by up to 25 percent.
“If rapamycin has a similar effect in dogs — and it’s important to keep in mind we don’t know this yet — then a typical large dog could live 2 to 3 years longer, and a smaller dog might live 4 years longer,” the project’s organizers write. “More important than the extra years, however, is the improvement in overall health during aging that we expect rapamycin to provide.”
Rapamycin trials have already begun on 32 middle-aged golden retrievers, Labrador retrievers and German shepherds. Ranging from 6 to 9 years old, these dogs will spend several months on a low-dose rapamycin regimen in which researchers study age-related metrics like heart function, immune response, physical activity, body weight and cognitive measures. They’ll also follow these 32 dogs throughout the rest of their lives, looking for any significant changes in aging or life span.
And in phase two of the study, a second group of middle-aged dogs will enter a longer-term, low-dose rapamycin regimen “designed to optimize lifespan extension.” Based on mouse studies conducted both at UW and elsewhere, they anticipate the drug “could increase healthy lifespan of middle-aged dogs by 2-5 years or more.”
Rapamycin isn’t a miracle drug, however, and high doses have been linked to side effects like immune suppression and delayed wound healing. But as the DAP website argues, “these are greatly mitigated at the doses used to extend longevity, and both animal and human studies indicate that even mild adverse events are rare.”
Regular exercise and outdoor time are great ways to boost a dog’s quality of life. (Photo: Shutterstock)
While the idea of extending dogs’ lives is exciting, it’s important not to let quantity of life overshadow quality of life. We may never have full control over how long our dogs live, but we can make sure they live well while they’re here.
A good reminder of this comes from Pegasus, a Great Dane rescued from unscrupulous breeders in South Africa when she was 4 weeks old. Suffering from a pigment deficiency often associated with blindness and deafness, Pegasus wasn’t expected to live very long. Filmmaker Dave Meinert adopted her anyway, and decided to film her daily as she grew up. In May 2015, he released a time-lapse movie (see below) of her reaching adulthood that quickly went viral. And as he explains in the video, Pegasus’ prognosis only helped the pair live every day like it was their last.
“I still don’t know how long she is going to live,” Meinert admits. “But right now is pretty great.”
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Watching the video offers the most beautiful, and powerful, reminder of the unconditional love that we can share with our dogs! What a gift they give us!
Wouldn’t we all love a few more years of happy and healthy life for our beloved dogs.
Learning from Dogs 