The link above is to the home page of Unsplash for there are so many excellent photographs on there.
We had a lightning storm over the house on Thursday evening with, luckily, a small amount of rain. Indeed, Saturday afternoon the firefighters, including air tankers, were attempting to bring three fires to the North-East of us to a halt.
So the first photograph is of a similar storm just to give you an idea of what we watched on Thursday.
I was just idly browsing dog websites a couple of days ago and came across the Dog Aging Project. As their About page reports:
The goal of the Dog Aging Project is to understand how genes, lifestyle, and environment influence aging. We want to use that information to help pets and people increase healthspan, the period of life spent free from disease.
I have taken the liberty of sharing one of their blog posts with you (I can’t see that isn’t allowed!)
ooOOoo
Longer, healthier lives. Together.
Dog and Human Genetics: Similarity and Difference
July 26th, 2022
Your pup may be your “fur baby,” but how similar are you genetically? You may be surprised!
Did you know that dogs and people share over 17,000 special genes called orthologs? Each pair of orthologs is derived from the same common ancestor via vertical descent (speciation) and they tend to have similar functions. They are one of the main reasons why your pup is such an invaluable comparative animal model for studying human health. In fact, humans and dogs have numerous similarities even in those parts of the genome that aren’t genes (the noncoding part of the genome). When it comes to better understanding human health, your pup is our best friend!
Sometimes, the effects of a gene are identical between dogs and people. For example, the same version of EPAS1, a gene triggered by low-oxygen conditions, is shared by people living in the Tibetan Plateau and the dog lineages that developed there. Genetic changes in this gene have taken place to help kickstart the body’s responses to hypoxia, or low oxygen levels, at high altitudes.
In other cases, the effects of a gene may be similar but not identical. For instance, the gene SCN3A is important to brain function and affects the development of speech. In children, mutations in SCN3A have been reported to cause disorders like epilepsy. But in dogs, genetic changes near the canine ortholog of SCN3A are associated with the frequency of howling in dogs.[1] The functions of this gene seem distinct (speech versus howling) but related!
For other health conditions shared by dogs and people, the same genes may not be responsible, but that doesn’t mean that research on those conditions in dogs isn’t helpful for humans! By learning more about how a dog’s genes are connected with a shared health condition, we can investigate the biological mechanisms involved and potentially make links to human health.
For example, people long suggested that narcolepsy might be a disease of the immune system: an autoimmune attack that causes daytime drowsiness and sudden sleep. In human studies, it was difficult to confirm the immune system link. It wasn’t until 1999[2] that this connection was discovered in a lineage of Doberman pinscher dogs. The researchers discovered a gene that is involved in the interface between the nervous system and immune system.
Finally, you and your pup share more than just genetics. Your environments are also very similar! You sleep in the same house—maybe even the same bed!—go on walks together, and breathe the same air. Interactions between these environmental variables and your genetics (called gene by environment interactions) can have an important impact on health. For example, smoking is well known to increase risk of bladder cancer in humans[3], but it is still unknown how secondhand smoke affects risk of bladder cancer in dogs.[4]
Data from the Dog Aging Project should help us answer important questions like these!
2. Ling Lin et al. 1999. The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene. Cell 98 (3): 365-376. https://doi.org/10.1016/S0092-8674(00)81965-0
3. JD Figueroa et al. 2014. Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis 35 (8):1737-44. https://pubmed.ncbi.nlm.nih.gov/24662972/
“Do what you can, with what you have, where you are.” “Believe you can and you’re halfway there.”“It is hard to fail, but it is worse never to have tried to succeed.”
“It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better.”
This famous quotation by Teddy Roosevelt (1858-1919), the 26th President of the USA, seems apt for today’s post.
Exactly one week ago I published a post called Musings from a 77 year old! I wrote that the future was uncertain. Summed up at one point by me writing: “I have no idea of the global changes that are afoot and how they will affect us in Merlin. Indeed, I have no idea how long I have to live.“
Margaret (from Tasmania) was one of the many people who responded. She included a video interview of Meg Wheatley by Michael Shaw. It is an hour long. Last Friday afternoon Jean and I watched it in full and it was incredibly interesting. Thank you very much, dear Margaret.
But before I present Meg’s video again I want to show you another video. It is a talk by Richard Grannon about the collapse of our civilisation. Now Richard Grannon is an author, YouTuber and life coach so one needs to remain impartial to his views, certainly before one does further research. But in the 46-minute talk I think there is much sense in what he says. See for yourself:
Moving on! The interview of Meg Wheatley is very good indeed. It’s a broad look at the issues and problems governing society but done in such a way that the people who watch her will also take away a number of tools for avoiding depression and anxiety. Meg places great store on the Hopi Native American Indians: “The Hopi maintain a complex religious and mythological tradition stretching back over centuries.“
Meg quotes one of the more famous Hopi prophecies, that is reproduced below:
This could be a good time! There is a river flowing now very fast. It is so great and swift that there are those who will be afraid. They will try to hold on to the shore. They will feel they are being torn apart and will suffer greatly. Know the river has its destination. The elders say we must let go of the shore, push off into the middle of the river, keep our eyes open, and our heads above the water.
And I say, see who is in there with you and celebrate. At this time in history, we are to take nothing personally, least of all ourselves. For the moment that we do, our spiritual growth and journey come to a halt.
The time of the lone wolf is over. Gather yourselves! Banish the word ’struggle’ from your attitude and your vocabulary. All that we do now must be done in a sacred manner and in celebration.
Here is that Meg Wheatley interview. (It is an hour long but very interesting; please watch it!)
I want to pick up the topic that was at the end of her interview; that of societal collapse. How would one define it? I chose Wikipedia for a reference.
Societal collapse (also known as civilizational collapse) is the fall of a complex human society characterized by the loss of cultural identity and of socioeconomic complexity, the downfall of government, and the rise of violence.[1]Possible causes of a societal collapse include natural catastrophe, war, pestilence, famine, economic collapse, population decline, and mass migration. A collapsed society may revert to a more primitive state, be absorbed into a stronger society, or completely disappear.
Virtually all civilizations have suffered such a fate, regardless of their size or complexity, but some of them later revived and transformed, such as China, India, and Egypt. However, others never recovered, such as the Western and Eastern Roman Empires, the Maya civilization, and the Easter Island civilization.[1] Societal collapse is generally quick[1] but rarely abrupt.[2] However, some cases involve not a collapse but only a gradual fading away, such as the British Empire since 1918.[3]
Anthropologists, (quantitative) historians, and sociologists have proposed a variety of explanations for the collapse of civilizations involving causative factors such as environmental change, depletion of resources, unsustainable complexity, invasion, disease, decay of social cohesion, rising inequality, secular decline of cognitive abilities, loss of creativity, and misfortune.[1][4] However, complete extinction of a culture is not inevitable, and in some cases, the new societies that arise from the ashes of the old one are evidently its offspring, despite a dramatic reduction in sophistication.[4] Moreover, the influence of a collapsed society, such as the Western Roman Empire, may linger on long after its death.[5]
The article is much more extensive than I have quoted above and for anyone deeply interested then I do recommend you going to the article and reading it extensively.
Now Meg is of the opinion that it is too late to turn back but next Tuesday I want to talk to you about Sir David Attenborough’s film A Life on our Planet. That he believes there is a chance to undo the harm we are causing to the planet; through rewilding.
Learning from Dogs 